Anterior poliomyelitis is a highly infectious disease that attacks the anterior horn of the spinal cord. Polio results in inflammation of the gray matter of the spine. Poliomyelitis is caused by a picorna virus that enters the body through the mucous membranes and then multiplies in the throat and, being an acidophilus, can survive well in the stomach and small intestine. When viremia occurs and persists, the virus will penetrate the capillary wall. Once this happens, it enters the central nervous system and begins to attack motor neurons. Polio is tissue-specific and multiplies and attacks only neurons. “This rigid neuronotropism and defined tissue specificity of the polio virus are reflected not only in its limited adult host range, but also in its inability to multiply in the undifferentiated embryonic tissues of the chick or mouse in which so many others have been cultured. virus". (Sabin) Picornaviridae are non-enveloped and are exceptionally small, single-stranded, positive-sense RNA. Its replication occurs in the cytoplasm and is also distinguished by its internal ribosomal entry site. Although polio is also called infantile paralysis, it doesn't just affect children. It does not discriminate and the older the person is when they contract it, the more likely paralysis is. Polio is transmitted from person to person, mainly through the fecal-oral route. This particular pathway can occur when drinking water comes into contact with fecal matter and is not treated adequately, improperly, or without washing hands after coming into contact with feces, after preparing food, or in the presence of matter fecal or even diseases. vectors such as the common housefly. While 90% of those infected are actually asymptomatic, the other 10% have a lot to…half of the paper…holder and continue to quarantine people. People were very against the quarantine. If a sterile environment could not be set up at home, they were forced to go to hospital. At that time, people were afraid of the hospital, because it was not clean and many died from secondary infections when they entered. Many hid their sick loved ones, which only led to further infections. Houses were marked with signs (figure 5) warning people of the presence of infected people, and guards were stationed at train stations to prevent sick people from travelling. Due to the high infection rate and lack of knowledge about the disease, all researchers could do was use observational epidemiology and inform the public about where outbreaks were occurring and how many people were infected while they continued to search for a cure. A cure in the form of a vaccine that would not arrive for 40 years.