Since the Renaissance, many scientists have shown a particular interest in the appendix, with the first drawings of the appendix in 1492 and later the first description of the appendix in 1521( Prystowsky, Pugh, & Nagle, 2005). The function of the appendix in adult humans is not yet clear, but is probably related to the role of lymphoid tissue in immunological processes (Debas, 2004). It was not until 1711 that the first account of appendicitis was reported and then verified in an autopsy of a criminal (Prystowsky, Pugh & Nagle, 2005). In this account, appendicitis was described as a gangrenous appendix with a small perforation. Today, appendicitis is considered an inflammation of the inner lining that has the ability to spread to other parts. Interestingly, the cause of appendicitis remains unknown, as over half of appendicitis cases remain elusive, but regardless of the specific details of the specific case of appendicitis or the course of treatment decided upon, there is universal agreement that the best outcomes of Acute appendicitis is associated with early diagnosis. To understand the pathophysiology of appendicitis you must first have a general understanding of the anatomy of the appendix. The appendix arises from the cecum and, like the cecum, includes circular and longitudinal muscle layers (Prystowsky, Pugh, & Nagle, 2005). Furthermore, the appendix contains many lymphatic follicles in its submucosa. The appendix is ​​located approximately 2.5 cm below the ileocecal valve and is usually 5 to 10 centimeters long with an average width of 0.5 to 1 centimeter. Although part of the appendix appears to be continuous with the cecum, the rest of the appendix is ​​free, which explains its va...... middle of paper... in the Renaissance, appendicitis is a common condition occurring in 250,000 patients in the United States each year (Prystowsky, Pugh, & Nagle, 2005). In addition to its controversial cause, the diagnosis of appendicitis can be complicated. The diagnosis of appendicitis can be made through a physical exam or with imaging techniques, but regardless of how appendicitis is diagnosed, it is always critical that appendicitis is diagnosed early in the disease. The combination of early diagnosis and surgical treatment promises the elimination of disease progression before the point of perforation, which is associated with increased morbidity. However, diagnosing appendicitis becomes more difficult in atypical cases, such as those involving the elderly, young children, those with a uniquely positioned appendix, or those with a complicated medical history.